My Honest AgelessRX Review As a Runner in my 40’s

If you’ve started to think about longevity or perimenopause and that’s taken you down a rabbit hole of supplements, I feel you. AgelessRX came on my radar in 2024 after a deep dive on researching LDN. Because I was ready to keep training, but my body felt different and I needed to figure out how to support it.

Because most runners I work with aren’t looking for shortcuts. They’re already doing the things:

• training consistently
• dialing in nutrition
• prioritizing sleep (or at least trying to)

And yet… sometimes something still feels off.

Energy dips. Recovery lags. That underlying “blah” feeling that’s hard to explain, but very real. I was finding this not just in myself, but in so many of our runners over 40 that I wanted to explore options. The supplement market has an option for everything, but again I wanted something with a bit more proof behind it and I was open to being the guinea pig for the group.

I’m so glad I was.

What is AgelessRX?

An extremely important distinction, AgelessRx isn’t a supplement company. It’s a telehealth platform.

That means everything is overseen by U.S.-licensed physicians, it’s HIPAA-compliant, and they work with compounding pharmacy partners to provide treatments that are typically harder to access through a traditional doctor’s office.

The goal is really about making longevity-focused care more accessible and personalized.

If you decide to explore it, you’re not just clicking “add to cart.” There’s a screening process to determine if something is appropriate for you, and ongoing check-ins to help manage dosing along the way.

They offer a wide range of options—things like NAD+, LDN, Metformin, GLP-1s, Sermorelin, Rapamycin, B12, and more. I can’t speak to all of those, and I won’t pretend to. But I can share my experience with LDN and NAD+, which are the ones I’ve spent time researching and testing myself.

And the reason I even went down this path comes back to what I’m seeing every day as a coach.

At this point, over 60% of our one-on-one athletes are women navigating perimenopause or menopause (and yes, plenty of men over 40, too). Which means we’ve had a front-row seat to how shifting hormones can show up differently for everyone.

But there are definitely patterns.

The most common things we hear?
Persistent, random aches.
Sleep disruptions.
And that underlying fatigue that doesn’t quite match the effort you’re putting in.

Which lead me to look at what can I do beyond smart training to better support my changing body (and my athletes!).

How Does it Work

• Online intake form / medical questionnaire
• Physician reviews and approves (or declines) your prescription
• Medication ships directly to your door from a compounding pharmacy.
• I’ve had no issues with pausing when I didn’t need and found it super easy to cancel one subscription when I decided it wasn’t the right time for me.
• Note: some states require a video consult first
• ID verification required
• Subscription based!! This is the one odd complaint from people, but it’s clearly marked it auto renews and as noted I found it super easy to turn off all by myself without calling or using online support.

Low Dose Naltraxone for Aches, Cravings and Brain Fog

Low Dose Naltrexone (LDN) is a much smaller dose of a medication originally used in higher doses for other medical conditions.

At low doses (typically ~1–4.5 mg), it appears to work differently, primarily by:

• supporting the body’s endorphin production
• modulating the immune system
• helping reduce inflammation

This is where it gets interesting for runners.

Because when we talk about feeling better, running stronger, and recovering well… we’re really talking about those exact systems.

When I entered perimenopause I went from being an athlete who rarely had injuries or more than a little twinge here an there to someone with random aches everyday. I felt comfortable starting hormone replacement therapy and that made a difference in alleviating the unexplained injuries, but there was still aches that made no sense.

I did a ton of research on LDN and felt like AgelessRX was a reliable place to test it out.

LDN is still an emerging area of research, but there are some promising studies, particularly around inflammation, pain, and immune response.

• A study on fibromyalgia found that LDN reduced pain and improved mood in participants
• Research published in Clinical Rheumatology showed improvements in symptoms for people with Crohn’s disease and other inflammatory conditions
• A review in Frontiers in Immunology highlighted LDN’s potential role in regulating the immune system and reducing chronic inflammation

While these aren’t running specific studies, they point to something relevant: when inflammation and immune function improve, people tend to feel better overall.

And when you feel better… you train better.

What were my results?

Some I expected and some I didn’t, but all were enough that I quietly recommended it to close friends over the next year and saw many of them have big changes too.

The thing to remember is these aren’t instant overnight magic results. This isn’t a pain killer, but it is something that for me made a significant change in my overall feeling.

• Reduced the chronic inflammation, so my random ankle pain or sudden neck pain stopped
• Reduced sugar cravings which was super helpful as we don’t process sugar as well with perimenopause
• Improved sleep
• My mood also felt elevated

Friends with autoimmune issues found their body felt better and another with ADHD even found it helped them with the brain fog. I’m not calling it a cure all or a miracle drug. All of us are still practicing good sleep hygiene, hydrating, fueling and working out.

But it felt like it was making those pieces easier again.

NAD+ for Energy and Brain Fog

When I first started sharing about HRT, one of the most interesting responses I got was from women who said, “I’m not ready for that yet… but I tried NAD+ and felt amazing.”

Energy. Mood. Mental clarity.
It kept coming up over and over again.

So like with LDN, I decided to stay open to a new idea and try it myself.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell in your body, and it plays a central role in how we produce energy at the cellular level—specifically inside the mitochondria, which are essentially the engines driving everything from your workouts to your recovery. Research shows that NAD+ levels decline as we age, and that drop is tied to changes in mitochondrial function, metabolism, and overall cellular health.

That’s a big part of why it’s getting so much attention in the longevity space.

There’s also growing research looking at how supporting NAD+ levels may influence aging pathways, inflammation, and muscle function. For example, a recent paper in Biochemical and Biophysical Research Communications explores how NAD+ precursors could play a role in age-related diseases by supporting cellular repair processes and energy metabolism.

And in more applied physiology, studies have shown that restoring NAD+ levels in aging muscle can improve mitochondrial function, reduce oxidative stress, and even enhance endurance and recovery in preclinical models.

So when people say they “feel better,” there is at least a physiological hypothesis behind it.

I tried NAD+ as a nasal spray after hearing all those positive experiences. And for me? It was… fine.

Not bad, not life-changing. I didn’t notice a dramatic shift in energy or recovery, and ultimately decided it wasn’t something I wanted to keep investing in long-term. The upside: it was easy to try, and just as easy to stop.

Should You Try LDN or NAD+?

And I think that last point is a really important part of this conversation.

Because while the science is promising, it’s still evolving. A lot of the strongest data is not in runners navigating real-life training, stress, sleep, and hormones all at once.

But that doesn’t mean it’s not worth exploring.

It just means we approach it the same way we approach training: with curiosity, context, and a willingness to adjust.

For some, they might be a meaningful lever for energy and recovery. For others, it might be neutral.

We’re on the cusp of a time where suddenly aging, perimenopause and menopause are being studied, discussed more openly and thought about with solutions. BUT we don’t have all the answers yet and I can absolutely say that the experience varies by person.

So I’m just hopeful that by sharing more and talking about it, I give others information I wish I’d had on day one of realizing something is different and not knowing how to resolve it.

This isn’t a sponsored review, but my experience with LDN was so good that after a year I reached out to AgelessRX.com because I really wanted to share. They were kind enough to provide a discount code for 10% any first purchase.

Ageless RX Discount Code: RUNTOTHEFINISH

Personally I trust them and have liked all the communication and service that not just I’ve received, but what I’ve seen in friends who have tried it.

What to read next?

• How to Adapt for Running over 50